The cover features 3′ end processing of replication-dependent histone pre-mRNA. Histone pre-mRNA (top wire) is cleaved 5 nucleotides after the stem loop by CPSF-73, represented by the wire cutter.
We've worked closely with the editors and the scientists who are featured in the article to create a design that best illustrates the discovery. Using the flashlight in the cover is descriptive of the discovery as well as a nice play on words to the title "FLASH Illuminates Histone Pre-mRNA 3' End Clevage."
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